In Vivo Cancer (Xenograft) Studies

Xenograft Studies

WBI offers efficacy tests for potential anti-cancer compounds:

• Our experienced personnel provide quality results and skilled observations
• The WBI Price Quote is clear, complete and designed to fit your budget.
• We provide "Firm Price" Quotations - no add-ons!
• Your Project scheduled and completed rapidly
• You receive 3 times weekly e-mail communications on developing results
• You receive a detailed Project Description – Custom Protocol, Schedule and Quotation
• You receive a Final Report including statistical/graphical analysis of the data.

You are invited to use our Protocols or we will customize to fit your Protocol.

Xenograft Models

Washington Biotechnology, Inc. has an in-house library of cell lines for validated xenograft mouse models. Our services include subcutaneous xenograft, orthotopic and syngeneic models, custom model development and MTD Determination.

We provide expert services at affordable prices and with rapid start-up of your Project.

If you need toxicity information on your test compound, we can determine MTD and recommend a dosing regimen.

• Subcutaneous xenograft models
• Orthotopic xenograft models
• Custom model development
• Maximum Tolerated Dose (MTD) Determination in SW mice - FREE with any xenograft order

Analysis and End Points:

• Primary tumor growth:  reported weekly with tabulated and graphed results
• Metastasis
• Metastatic growth
• Tumor growth recovery post-dosing
• Mortality
• Observations for toxic effects
• Recovery of tumors:  Preservation by flash-freezing, formalin or paraffin.

 Routes of Administration for Test Compounds or Vaccines:

• Oral
• Intravenous
• Intraperitoneal
• Subcutaneous
• Intranasal
• Intratracheal

  WBI offers Multiple Cell Lines  and Xenograft Models including :

In addition to our own models we offer services for :

§         Validation of any cell line for tumor growth.

§         Custom development of xenograft model for any tumorigenic cell line.

 Glioma Brain Cancer Model

WBI offers a subcutaneous xenograft model for athymic nude mice implanted with C6 glioma cells.

The efficacy of test compounds to inhibit tumor growth is measured over a 30-day period. Results are reported weekly. This is another rapid, reliable and economical WBI model for measurement of anti-proliferative efficacy.

For other models and other cell lines: Please inquire.