Inflammation Research Services - In Vivo Models - Rheumatoid Arthritis (RA) animal models,CIA, PIA, AIA ,CPE,Mouse Ear Edema, EAE/Peptide Mouse Models, WBA, Mouse LPS, Air Pouch Models (MSU, Human Gout),Streptococcal Cell Wall (SCW) PG-PS, IBD


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WASHINGTON BIOTECHNOLOGY, INC.

Now in our 24th Year of Service in Drug Development

In Vivo Inflammation Models

Drug & Vaccine Studies	Drug Development	Support Services	Custom Antibodies
Arthritis Models	Inflammation	Xenograft Studies	PK / TOX *Rapid-turnaround*

Inflammation

WBI offers a wide variety of economical, in vivo models to assess efficacy of anti-inflammatory test compounds. Our experienced technical personnel provide quality studies and experienced observations for your full information.

Your study receives our careful attention -

A WBI Project Manager assigned to every project.
A complete, detailed Protocol and Schedule is prepared for your acceptance before work begins.
During your study you will receive timely updates by e-mail on results, observations and schedule status.
Your completed Project is fully described in a Final Report including statistical/graphical analysis of results.

In Vivo Inflammation and Inflammatory Disease Models

Rheumatoid Arthritis (RA) Models

o Collagen-Induced Arthritis (CIA) *

o Pristane-Induced Arthritis (PIA)

o Adjuvant-Induced Arthritis (AIA)

o Ovalbumin-Induced Arthritis

o Air Pouch Model

o Zymosan Air Pouch Model

o PG-PS 10S Rat Model

Antigen-Induced Arthritis - measures acute and chronic responses in rabbit; large volumes for tissues and joints.
Carrageenan Paw Edema (CPE) - rapid one-day initial screen for anti-inflammatory activity; an inexpensive and reliable model.
Mouse Ear Edema Topical - an excellent measure of topical anti-inflammatory activity
Mouse LPS Model - cytokine analysis of LPS-stimulated inflammation
Inflammatory Bowel Disease (IBD) - Experimental Inflammatory Bowel Disease in Rodents
Streptococcal Cell Wall (SCW) PG-PS 10S Rat Model - a valuable model for assessment of the efficacy of therapeutic and prophylactic compounds on the acute and chronic inflammatory responses, especially for arthritis studies.
EAE/Peptide Mouse Models for Multiple Sclerosis (MS) -

o acute and remitting - PLP_139-151peptide-induced EAE Model in SJL Mice

o chronic, progressive - MOG_35-55peptide-induced EAE Model in C57BL/6 Mice.

* Collagen-Induced Arthritis (CIA) Sample Graphical Analysis of Results

Click to Enlarge

In Vitro Assays for Anti-inflammatory Efficacy Testing

To complement our In Vivo models, Washington Biotechnology offers In Vitro models for early screening of test materials:

Whole Blood Assay (WBA) - In Vitro assay measuring cytokine production/inhibition within inflamed whole human blood modeling the environment for actual drug activity

You can choose from additional WBI services to extend analysis of inflammatory effects as may be beneficial for your requirements: Blood samples, cytokines, clinical chemistries, cell counts and differentials, necropsy, organ removals and preservation, histologies.

Please contact us for further information and a custom quotation.