LPS Mouse Model
Current remedies for rheumatoid arthritis, multiple sclerosis, and related inflammatory cell-mediated diseases either attempt to ameliorate the pain and inflammation associated with the early stages of these diseases or suppress the immune system, resulting in the increased susceptibility to infectious disease. In the ongoing search for more effective treatments, investigations have focused on the blockade or inhibition of the cytokines released by these inflammatory cells. The activity of these cytokines released early in the cycle of disease development has been found to be directly related to the severity of the inflammation and subsequent tissue destruction.
The LPS Mouse Model is an accurate, reliable and inexpensive model which involves the activation of circulating white blood cells, diapedesis of these cells from the circulation to the peritoneal cavity, and the stimulation of these cells to release cytokines.
|LPS Mouse Study|
Fast, accurate, reliable and inexpensive model for anti-inflammatory efficacy
|Groups||Vehicle, positive control (prednisolone or various others), test compound(s)|
|Study Duration||1 day|
|Readouts||Cytokines (TNF-alpha, IL-6, IL-17, IL-1 beta and others)|