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  • In Vivo CRO Services
    • Autoimmune & Inflammatory Diseases
      • Multiple Sclerosis
      • Gout
      • Inflammatory Bowel Disease (IBD)
      • Dermatitis (Contact)
      • Lupus
      • Nephritis
      • Pancreatitis
      • Hepatitis
      • Psoriasis
      • Pulmonary Fibrosis
      • Diabetes
      • General Inflammation Assessment
      • Acute Choleostasis Model
    • Rheumatoid Arthritis
      • Collagen-Induced Arthritis Model
      • Adjuvant-Induced Arthritis Model
      • Carrageenan Air Pouch Model
      • Zymosan Air Pouch Model
      • Pristane-Induced Arthritis Model
      • Ovalbumin-Induced Arthritis Model
      • SCW PG-PS 10S Rat Model
      • Arthritis Combo Testing: Rodent/Rabbit
    • Cancer
      • WBI Cell Lines for Cancer Models
      • Xenograft, Orthotopic & Syngeneic Models
    • Bacterial Infection
      • MRSA Model
      • Listeria Model
    • Pain Studies
      • Formalin Test (Chemical Sensitivity)
    • Pharmacokinetics and Toxicity
      • Pharmacokinetics (PK)
      • Toxicity and MTD Studies
    • Support Services
      • In Vitro Compound Screening for Anti-inflammatory Activity
    • WBI Project Management
  • About Us
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  • Contact Us
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  • In Vivo CRO Services
    • Autoimmune & Inflammatory Diseases
      • Multiple Sclerosis
      • Gout
      • Inflammatory Bowel Disease (IBD)
      • Dermatitis (Contact)
      • Lupus
      • Nephritis
      • Pancreatitis
      • Hepatitis
      • Psoriasis
      • Pulmonary Fibrosis
      • Diabetes
      • General Inflammation Assessment
      • Acute Choleostasis Model
    • Rheumatoid Arthritis
    • Cancer
    • Bacterial Infection
    • Pain Studies
    • Pharmacokinetics and Toxicity
    • Support Services
    • WBI Project Management
  • About Us
  • What's New
  • Contact Us
  • Sitemap
  • Careers

Autoimmune & Inflammatory Diseases

 

WBI offers a wide variety of economical in vivo models to assess efficacy of anti-inflammatory test compounds in autoimmune/inflammatory diseases and general inflammation:

 

Disease Description Model(s)
Multiple Sclerosis Multiple sclerosis (MS) is a chronic neurodegenerative and inflammatory disease of the central nervous system (CNS) that represents one of the most prevalent human autoimmune diseases.

PLP Peptide - acute/remitting


EAE Rat – acute/remitting


MOG Peptide – chronic/progressive

Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of joints and organs.

Collagen-induced Arthritis (CIA)

Adjuvant-induced Arthritis (AIA)

Carrageenan Air Pouch

Pristane-induced Arthritis (PIA)

Ovalbumin-induced (OIA) Arthritis

SCW PG-PS 10S

Arthritis Combo-Test

 

Gout

Gout is a chronic form of arthritis caused by a build-up of uric acid in blood with subsequent formation of uric acid deposits in the joints.

 

Air Pouch MSU (Gout)

Inflammatory Bowel Disease

 

Inflammatory Bowel Disease (IBD) is a group of autoimmune inflammatory conditions of the colon and small intestine that results in perforating ulcers.

TNBS-induced (acute)


Indomethacin-induced (Small Intestine Injury)


DSS-induced (acute)


DSS-induced (chronic)

 

Dermatitis (Contact) Contact dermatitis is a type of skin inflammation that occurs when substances touching the skin cause edema or an allergic reaction.

Delayed Type Hypersensitivity (DTH) Reaction

 

Lupus

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that currently has no cure. Investigative therapies are aimed at relief of symptoms.

 

SLE Mouse Model

Nephritis

 

Nephritis is an inflammation of one or both kidneys most often caused by autoimmune disease (lupus) but also triggered by other factors such as infection.

 

PA-induced Nephritis


Antibody-induced Nephritis

Pancreatitis

 

Acute pancreatitis in humans is characterized by edema, cell necrosis and severe inflammation of the pancreas. The disease causes elevated blood and urine levels of the pancreatic digestive enzymes amylase and lipase.

 

Caerulein-induced acute pancreatitis

Autoimmune 
​Hepatitis

 

Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver characterized by breakdown of self-tolerance leading to the appearance of autoantibodies (ANA, SMA, other).

 

CON A -Induced Hepatitis

Psoriasis

 

Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders involved in the dysregulated interplay between immune cells and keratinocytes.

 

IMQ Psoriasis Model
Pulmonary Fibrosis Pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF), is a chronic progressive and ultimately fatal lung disease of unknown etiology. Bleomycin-induced Mouse Model

Diabetes

 

Diabetes mellitus of Type II Diabetes refers to a group of diseases that affect how the body uses blood glucose.

 

STZ-induced (rat)
General Inflammation

General Inflammation, the body’s response to harmful stimuli, can be either acute or chronic.

 

Carrageenan Paw Edema (CPE) Model

LPS Model

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Our experienced technical personnel provide quality studies and experienced observations for your full information. With WBI’s Project Control and Communications (PCC), you are assured of timely communications and close tracking of the progress of your study.

 

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