Autoimmune & Inflammatory Diseases
WBI offers a wide variety of economical in vivo models to assess efficacy of anti-inflammatory test compounds in autoimmune/inflammatory diseases and general inflammation:
| Disease | Description | Model(s) |
| Multiple Sclerosis | Multiple sclerosis (MS) is a chronic neurodegenerative and inflammatory disease of the central nervous system (CNS) that represents one of the most prevalent human autoimmune diseases. | |
| Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of joints and organs. |
Collagen-induced Arthritis (CIA) Adjuvant-induced Arthritis (AIA) Pristane-induced Arthritis (PIA) Ovalbumin-induced (OIA) Arthritis
|
|
|
Gout is a chronic form of arthritis caused by a build-up of uric acid in blood with subsequent formation of uric acid deposits in the joints.
|
||
|
|
Inflammatory Bowel Disease (IBD) is a group of autoimmune inflammatory conditions of the colon and small intestine that results in perforating ulcers. |
|
| Dermatitis (Contact) | Contact dermatitis is a type of skin inflammation that occurs when substances touching the skin cause edema or an allergic reaction. |
Delayed Type Hypersensitivity (DTH) Reaction
|
| Lupus |
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that currently has no cure. Investigative therapies are aimed at relief of symptoms.
|
SLE Mouse Model |
|
|
Nephritis is an inflammation of one or both kidneys most often caused by autoimmune disease (lupus) but also triggered by other factors such as infection.
|
|
|
|
Acute pancreatitis in humans is characterized by edema, cell necrosis and severe inflammation of the pancreas. The disease causes elevated blood and urine levels of the pancreatic digestive enzymes amylase and lipase.
|
Caerulein-induced acute pancreatitis |
|
|
Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver characterized by breakdown of self-tolerance leading to the appearance of autoantibodies (ANA, SMA, other).
|
CON A -Induced Hepatitis |
|
|
Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders involved in the dysregulated interplay between immune cells and keratinocytes.
|
IMQ Psoriasis Model |
| Pulmonary Fibrosis | Pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF), is a chronic progressive and ultimately fatal lung disease of unknown etiology. | Bleomycin-induced Mouse Model |
|
|
Diabetes mellitus of Type II Diabetes refers to a group of diseases that affect how the body uses blood glucose.
|
STZ-induced (rat) |
| General Inflammation |
General Inflammation, the body’s response to harmful stimuli, can be either acute or chronic.
|
Our experienced technical personnel provide quality studies and experienced observations for your full information. With WBI’s Project Control and Communications (PCC), you are assured of timely communications and close tracking of the progress of your study.