Remitting-Relapsing MS (EAE PLP Mouse Model)
PLP139-151 peptide-induced EAE Model in SJL Mice is known to be a well-suited tool to experimentally address mechanisms that cause the remitting-relapsing autoimmune pathology of the CNS of MS patients and to evaluate the efficacy of test compounds for curing or preventing MS.
PLP139-151 is extensively expressed in the CNS and causes lesions that resemble many features of MS and clinically show symptoms of the remitting-relapsing disease phenotype. Many other physical features including limp tail, hind and/or front legs weakening or complete paralysis are observed and scores as indexes of disease severity.
|PLP 139-151 Peptide-induced EAE Model in SJL Mice|
|Features clearly defined disease parameters and scoring in reliable protocols for prophylactic or therapeutic efficacy testing.|
|Groups:||Vehicle, compound, positive control|
|Study Duration:||9 weeks|
|Readouts:||In vivo scoring, body weights|
|Optional:||Histology, PK sampling|