Chronic & Progressive MS (EAE MOG Mouse Model)
The administration of myelin protein derived peptides such as myelin oligodendrocyte glycoprotein 35-55 (MOG35-55) to susceptible mice such as the C57BL/6 mice strain has been shown to induce EAE.MOG35-55 is expressed in the CNS and causes lesions that resemble many features of MS and show clinical symptoms of the progressive chronic disease phenotype. Many other physical features including limp tail, hind and/or front legs weakening or complete paralysis are observed and scored as indexes of disease severity.
|MOG35-55 peptide-induced EAE Model in C57BL/6 Mice|
|Valuable model for assessment of potential efficacy in treatment of MS|
|Groups:||Vehicle, compound, positive control|
|Study Duration:||40 days|
|Readouts:||In vivo scoring, body weights|
|Optional:||Histology, PK sampling|