Washington Biotechnology
  • In Vivo CRO Services
    • Autoimmune & Inflammatory Diseases
      • Multiple Sclerosis
      • Gout
      • Inflammatory Bowel Disease (IBD)
      • Dermatitis (Contact)
      • Lupus
      • Nephritis
      • Pancreatitis
      • Hepatitis
      • Psoriasis
      • Pulmonary Fibrosis
      • Diabetes
      • General Inflammation Assessment
      • Acute Choleostasis Model
    • Rheumatoid Arthritis
      • Collagen-Induced Arthritis Model
      • Adjuvant-Induced Arthritis Model
      • Carrageenan Air Pouch Model
      • Zymosan Air Pouch Model
      • Pristane-Induced Arthritis Model
      • Ovalbumin-Induced Arthritis Model
      • SCW PG-PS 10S Rat Model
      • Arthritis Combo Testing: Rodent/Rabbit
    • Cancer
      • WBI Cell Lines for Cancer Models
      • Xenograft, Orthotopic & Syngeneic Models
    • Bacterial Infection
      • MRSA Model
      • Listeria Model
    • Pain Studies
      • Formalin Test (Chemical Sensitivity)
    • Pharmacokinetics and Toxicity
      • Pharmacokinetics (PK)
      • Toxicity and MTD Studies
    • Support Services
      • In Vitro Compound Screening for Anti-inflammatory Activity
    • WBI Project Management
  • About Us
  • What's New
  • Contact Us
  • Sitemap
  • Careers
  • In Vivo CRO Services
    • Autoimmune & Inflammatory Diseases
      • Multiple Sclerosis
        • Chronic & Progressive MS (EAE MOG Mouse Model)
        • Remitting-Relapsing MS (EAE PLP Mouse Model)
        • Remitting-Relapsing MS (EAE Rat Model)
      • Gout
      • Inflammatory Bowel Disease (IBD)
      • Dermatitis (Contact)
      • Lupus
      • Nephritis
      • Pancreatitis
      • Hepatitis
      • Psoriasis
      • Pulmonary Fibrosis
      • Diabetes
      • General Inflammation Assessment
      • Acute Choleostasis Model
    • Rheumatoid Arthritis
    • Cancer
    • Bacterial Infection
    • Pain Studies
    • Pharmacokinetics and Toxicity
    • Support Services
    • WBI Project Management
  • About Us
  • What's New
  • Contact Us
  • Sitemap
  • Careers

Multiple Sclerosis

 

Multiple sclerosis (MS) is a chronic neurodegenerative and inflammatory disease of the central nervous system (CNS) that represents one of the most prevalent human autoimmune diseases. MS is a complex disease with heterogeneous clinical and pathological phenotypes. Clinically, MS may present as a relapsing-remitting disease or with steady progressive neurological disability.

Mouse and rat models of experimental autoimmune encephalomyelitis (EAE) acquired inflammatory and demyelinating autoimmune disease have been investigated extensively.

WBI EAE Models of Human Multiple Sclerosis

WBI has full services for analysis of test article efficacy in EAE Models of Human Multiple Sclerosis (human demyelinating disease).

Our comprehensive EAE services include:

  • Chronic Progressive MS (EAE MOG peptide-induced disease) in mouse
  • Remitting-Relapsing MS (EAE PLP peptide-induced disease) in mouse
  • Remitting-Relapsing MS (EAE Myelin basic protein-induced disease) in rat
  • Prophylactic and Therapeutic Protocols
  • Daily In Vivo Scoring and animal observations (results transmitted as collected so you see how your study is progressing).
  • Assessment of Spinal Cords for demyelination and inflammation.
  • Validated Controls: FTY720 and Dexamethasone.
  • Experienced technical staff and project management.
  • Rapid Scheduling: your study will start within 10 days of order.
  • Custom Protocol and Comprehensive Final Reports

Optional services that may be combined with EAE Studies:

  • PK sampling
  • Blood cell counts: CBC/differentials
  • Histopathology (inflammation and demyelination: brain/or spinal cords)
  • Cytokine measurements
  • Lymph node collections for B-cell analysis 
Contact Us
Request a Quote
What's New?
Read Our Newsletter

© Washington Biotechnology Inc., 2014. All Rights Reserved.
Built by Biz-Zone