Bleomycin-induced Mouse Model

Bleomycin-induced Mouse Model
The value of this model: Comprehensive assessment of therapeutic Flexible study design (selection of dosing routes and frequency; Client decision for histopathology) Economical
Species	Male C57BL/6 mice
Study Duration	21-day study in vivo
Method	Intratracheal administrationof Bleomycin for disease induction
Collections	Bronchoalveolar lavage fluids (BALF), lung tissue
Readouts	Body weights; BALF cell number, BALF total protein and cytokines, lung collagen content, lung tissue histopathology (lung parenchyma lesions detection by H&E stain and lung fibrosis score by Masson's trichrome stain)
Optional	Histopathology may be considered optional to be ordered following Client's review of cell, protein and collagen data.