Adjuvant-Induced Arthritis Model

 

Adjuvant-Induced Arthritis (AIA) Model

One of the longest established animal models for testing arthritis treatments

  • Reliable model with less well-defined mechanism than CIA or PIA
Species Rat
Groups
  • Vehicle
  • Positive Control (methotrexate, dexamethasone, Enbrel®, Abatacept™, other)
  • One group for each dose of each test compound
Test Duration 30 days
Readouts Paw volumes, body weights
Optional Histopathology, cytokines