Collagen-Induced Arthritis Model
|Collagen-Induced Arthritis (CIA) Model|
The “standard” animal model for evaluation of anti-arthritic activity based on immunization with bovine collagen to develop antibodies against bone and cartilage.
Mouse or Rat
|Test Duration||42 days|
|Readouts||Arthritic Index, body weights|
Paw volumes, histopathology, cytokines, collagen titers, popliteal lymph nodes