Services to complement WBI’s disease model efficacy testing include In Vitro Compound Screening, Formulations, Cardiovascular Screen Services and Necropsy.

WBI Support Services

In Vitro Compound Screening

Formulations

Cardiovascular Screen Services

Other: Tissue Culture Bacterial Culture Necropsy Organ, tissue collection and preservation (flash-frozen, formalin) MTT Assay ELISA Cytokine analysis Clinical Chemistry Cell Counts and Differentials Histology

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Formulations - To improve bioavailability of Active Pharmaceutical Ingredients, pharmaceutical formulation is very important in pharmaceutics. At WBI we recognize the importance of our clients' requirements to develop robust formulations. Considering some factors such as particle size, structure, polymorphism, pH, temperature and solubility, we can help our clients develop a bioavailable, stable and optimal dosage form for a specific administration route.

Cardiovascular Screen - Direct measurement of blood pressure and heart rate over hours or days in conscious rats provides a useful cardiovascular screen. Measurements in unrestrained rats accurately represent cardiovascular function without stress. Measurements are automatically taken and recorded every 10 seconds for prolonged periods (e.g. hours to weeks) and then averaged over time to give steady state information.

The direct blood pressure approach allows long-term pressure recordings under conditions of low stress. The technique is versatile and can be used for acute studies in anesthetized rats or long-term monitoring.

​Necropsy - Includes removal, weights, preservation and collection of designated organs for histology or shipment to your laboratory.